Oestrogen E3 0.3% Anti-ageing Face Cream 45g

Topical E3 ( Oestrogen) Cream is a wonderful cream to any menopausal and peri-menopausal skin regime. Applied each night.

Many studies have shown that upon entering menopause, women detect a swift commencement of skin aging symptoms (Thornton, 2013). One of the first symptoms experienced is increased skin dryness, followed by decreased firmness and elasticity (Castelo-Branco et al., 1992). These symptoms correspond with structural and architectural changes, such as decreased sebum production, collagen content, dermal thickness, and elastin fibers (Affinito et al., 1999, Raine-Fenning et al., 2003, Sumino et al., 2004, Verdier-Sévrain, 2007).

Estrogen helps retain and restore skin moisture through the promotion of sebum secretion, primarily by regulating the expression of insulin-like growth factor receptors and increasing the production of insulin-like growth factors from fibroblasts (Ashcroft et al., 1997), which in turn induces lipogenesis in human sebocytes and leads to moisture retention. Additionally, estrogen therapy elevates the levels of mucopolysaccharides and hyaluronic acids in the dermis to keep the skin hydrated (Grosman, 1973, Grosman et al., 1971), which improves the barrier function of the stratum corneum and optimizes the surface area of corneocytes (Duarte et al., 2016).